'astragalotibial' originates from Modern/Medical Latin and English anatomical formation, combining the Greek-derived element 'astragalo-' (from Greek 'astragalos', meaning 'ankle bone' or 'talus') with the Latin-derived adjective 'tibial' (from Latin 'tibia', meaning 'shinbone').

'astragalos' entered Latin as 'astragalus' (meaning the talus or anklebone); in modern anatomical English, the combining form 'astragalo-' was joined with the adjective-forming element from Latin 'tibialis' (via 'tibial') to create 'astragalotibial', used in medical descriptions.

Initially elements referred separately to the talus ('astragalo-') and the shinbone ('tibial'); over time the combined form came to specifically denote structures or relations involving both the talus and the tibia (e.g., ligaments, articulations).