'astragalocalcaneal' originates from Neo-Latin/modern medical formation combining Greek and Latin elements, specifically the Greek word 'astragalos' and the Latin word 'calcaneus', where 'astragalos' meant 'ankle bone (talus)' and 'calcaneus' meant 'heel'.

'astragalocalcaneal' changed from the combining forms 'astragalo-' (from Greek 'astragalos') and 'calcaneal' (from Latin 'calcaneus') used in Neo-Latin anatomical terminology and eventually became the modern English medical adjective 'astragalocalcaneal'.

Initially it referred to the bones 'astragalus' and 'calcaneus' (i.e., the talus and heel bone), but over time it evolved into its current usage meaning 'pertaining to the articulation or region involving the talus and calcaneus (talocalcaneal/astragalocalcaneal joint)'.