'aspermous' originates from New Latin/Greek, specifically from the Greek elements 'a-' and 'sperma', where 'a-' meant 'not' and 'sperma' meant 'seed' or 'semen'.

'aspermous' was formed in scientific usage by combining the privative prefix 'a-' with Greek 'sperma' (seed), passing through New Latin/Neo-Latin formations into modern English as a technical biological term in the 19th–20th century.

Initially it meant 'without seed' or 'without sperm'; over time it has remained a specialized biological term with essentially the same technical meaning of lacking sperm or seed.