'aspermic' originates from Greek-derived elements: the privative prefix 'a-' meaning 'without' and the root 'sperm(-, sperma)' (from Greek 'sperma') meaning 'seed' or 'sperm'.

'aspermic' developed in modern medical English from nouns/adjectives formed with the privative 'a-' + 'spermic' (related to 'sperm' from Greek 'sperma' via Latin/modern scientific usage), producing the adjective 'aspermic' to describe absence of sperm.

Initially the components implied 'without seed' in a broad sense; over time the term came to be used specifically in medical contexts to mean 'without sperm' or 'lacking semen containing sperm'.