'aphrodisiomaniacal' originates from Greek/New Latin, specifically the elements 'aphrodisios' (from Greek 'Aphrodite', associated with love/sexual desire) and 'mania' (from Greek 'μανία'), where 'aphrodisios' related to sexual desire and 'mania' meant 'madness' or 'frenzy'.

'aphrodisiomaniacal' developed from the medical/psychological noun 'aphrodisiomania' (formed in New Latin/19th-century usage from Greek roots) and was later converted into the adjective 'aphrodisiomaniacal' by adding the adjectival suffix '-al'.

Initially it referred specifically to a pathological 'madness' or clinical condition of excessive sexual desire; over time it has also been used more generally or figuratively to describe extreme or obsessive sexual desire.