'aortostenosis' originates from Modern Latin/medical New Latin and Greek, specifically the Greek words 'aorta' (αορτή) and 'stenosis' (στένωσις), where 'aorta' meant 'the main artery' and 'stenosis' meant 'narrowing'.

'aortostenosis' developed as a modern medical compound combining the Greek roots 'aorta' + 'stenosis'; it is closely related to the phrase 'aortic stenosis' and entered English via medical Latin usage in the 19th–20th centuries.

Initially, the component roots described 'the aorta' and 'narrowing'; over time the compound came to denote the clinical condition 'narrowing of the aorta' (or aortic region) in modern medical usage.