'aortopathy' originates from Modern English/New Latin, specifically composed of 'aorta' + the suffix '-pathy', where 'aorta' referred to the large main artery (from Greek) and '-pathy' meant 'disease' or 'suffering'.

'aorta' comes from Greek 'aortē' (αορτή), passed into Latin as 'aorta' and then into English; the combining form '-pathy' derives from Greek 'pathos' via New Latin medical formation. In modern medical English these elements were combined to coin 'aortopathy'.

Initially the roots referred separately to 'the great artery' ('aorta') and 'disease/suffering' ('-pathy'); over time the combined form came to specifically denote 'disease of the aorta' in clinical contexts.