'antipathize' originates from Greek via Late Latin and French, specifically the word 'antipathēs' (through English 'antipathy') where 'anti-' meant 'against' and 'pathos' meant 'feeling', combined with the suffix '-ize' (from Greek '-izein') used to form verbs.

'antipathize' developed in English by combining the noun 'antipathy' (from French/Latin/Greek) with the verb-forming suffix '-ize'; English forms such as French 'antipathiser' and constructions using 'antipathy' + '-ize' contributed to the modern English 'antipathize'.

Initially it conveyed the idea 'to have or experience antipathy (a feeling against)', but over time it has come to mean more specifically 'to feel or show hostility, dislike, or opposition toward someone or something'.