'antignostical' originates from Modern English, specifically formed from the prefix 'anti-' and the adjective 'gnostical' (from 'gnostic'), where 'anti-' meant 'against' and 'gnostical' related to 'gnosis' meaning 'knowledge'.

'antignostical' was formed in English by attaching the productive prefix 'anti-' to 'gnostical'; 'gnostical' ultimately derives from Greek 'gnōstikos' (knowledge-able) via Latin/Neo-Latin 'gnosticus' and English 'gnostic'/'gnostical'.

Initially it meant 'against Gnosticism or the Gnostics' specifically, but it has also been used more broadly to mean 'opposed to certain kinds of (especially esoteric or spiritual) knowledge'.