'antifebrin' is a modern coinage formed from the combining form 'anti-' (against) and elements derived from Latin 'febris' (fever) (via French 'fébrine'), created as a trade name for a fever-reducing drug.

'antifebrin' was coined in the late 19th century as a commercial name for the compound acetanilide; acetanilide itself is named from 'acetic' + 'aniline' (chemical roots) and entered medical use in that period.

Initially it meant 'a medicine to reduce fever' specifically referring to acetanilide; over time the term became obsolete as the drug fell out of medical use and is now mainly of historical interest.