'antidysuritic' originates from modern New Latin and Greek elements: the prefix 'anti-' (Greek 'anti', meaning 'against'), the combining form 'dys-' (Greek 'dys', meaning 'bad' or 'disordered'), and 'ur-' from Greek 'ouron' meaning 'urine', plus the adjectival/agent-forming suffix '-itic'.

'antidysuritic' was coined as a medical formation in New Latin/medical English in the late 19th to early 20th century from Greek components ('anti-' + 'dys-' + 'ouron') and entered English usage as a technical term for agents acting against dysuria.

Initially coined to denote agents acting 'against dysuria' (i.e., preventing dysuria), the term's use has broadened to include agents that more generally 'relieve' or 'alleviate' painful or difficult urination.