'anti-manic' originates from Modern English, combining the prefix 'anti-' (from Greek 'anti-' meaning 'against') with 'manic' (from Greek 'mania' meaning 'madness' or 'frenzy').

'anti-' comes from Greek 'anti-' and was adopted into English as a productive prefix meaning 'against'; 'manic' derives from Greek 'mania' (via Latin usage in medical terminology). The compound 'anti-manic' developed in 20th-century medical English to describe treatments opposing mania.

Initially formed to mean 'against mania' in a literal medical sense; the meaning has remained stable and is used specifically for drugs or interventions that counteract manic symptoms.