'anti-aphrodisiac' originates from Modern English, formed by the prefix 'anti-' (from Greek 'anti-' meaning 'against') combined with 'aphrodisiac' (from Greek 'aphrodisiakos', relating to Aphrodite).

'aphrodisiac' comes from Greek 'aphrodisiakos' (from 'Aphrodite'), passed into Late Latin and then into English; 'anti-aphrodisiac' was formed in English by adding the productive prefix 'anti-' to 'aphrodisiac'.

Initially 'aphrodisiac' meant 'relating to Aphrodite or stimulating sexual desire'; 'anti-aphrodisiac' has consistently meant 'countering or inhibiting sexual desire', with little shift in basic sense since formation.