'antaphroditic' originates from Modern formation in English, specifically combining the prefix 'anti-' (from Greek via Latin, meaning 'against') and the element 'aphroditic' (from 'Aphrodite', the Greek goddess of love), where 'anti-' meant 'against' and 'Aphrodite' referred to love/sexual desire.

'antaphroditic' was formed by analogy with words such as 'antaphrodisiac' (a substance that reduces sexual desire) and by combining 'anti-' + 'aphroditic' in modern English; it did not pass through a long Middle English history but is a relatively recent English coinage.

Initially it meant 'against or opposing sexual desire' and over time it has retained that basic sense, used descriptively for agents or qualities that reduce libido.