'anodyne' originates from Greek, specifically the word 'anodynos,' where 'an-' meant 'without' and 'odynē' meant 'pain.'

'anodynos' transformed into the Latin word 'anodynus,' and eventually became the modern English word 'anodyne' through Middle English.

Initially, it meant 'without pain,' but over time it evolved into its current meaning of 'pain-relieving.'