'anglophobiac' originates from English, specifically the combining forms 'Anglo-' (from Medieval Latin 'Anglus', meaning 'an Angle; English') and 'phobia' (from Greek 'phóbos', meaning 'fear'), plus the suffix '-iac' (from Greek '-iakos' via Latin '-iacus' and French '-iaque'), where '-iac' meant 'one affected with' or 'pertaining to'.

'Anglo-' and 'phobia' were combined with the suffix '-iac' in modern English to create the form 'anglophobiac', and this formation eventually became the modern English word 'anglophobiac'.

Initially, it meant 'a person afflicted with or characterized by Anglophobia,' and this meaning has largely remained the same in modern usage.