'angiodestructive' originates from Greek and Latin-derived English elements: the Greek combining form 'angio-' (from Greek 'angeion' meaning 'vessel') combined with the English adjective 'destructive' (from Latin roots related to 'destruere', 'to tear down').

'angiodestructive' is a modern compound formed in English by joining the Greek-derived combining form 'angio-' (vessel) with the established English adjective 'destructive' (itself from Latin 'destruere' via Old French), resulting in the technical adjective used in medicine.

Initially formed to literally mean 'vessel-destroying' for descriptive medical use; it has retained that specialized meaning in modern clinical and pathological contexts.