'aneuploidic' originates from modern scientific coinage formed from the root 'aneuploid' plus the adjectival suffix '-ic'. The element 'aneu-' is a combining form built from Greek 'an-' (meaning 'not' or 'without') combined with the element 'ploid' (from New Latin/Greek roots related to 'fold' or 'multiplicity' used in terms like 'haploid' and 'diploid').

'aneuploid' was coined in 20th-century cytogenetics (from New Latin/Greek combining forms) to describe cells with an abnormal chromosome number; adding the English adjectival suffix '-ic' produced 'aneuploidic' to mean 'relating to aneuploidy'.

Initially, the formation described the concept 'not of the usual fold or multiple (in chromosome number)'; over time it came to be used specifically to mean 'relating to or exhibiting an abnormal number of chromosomes'.