'anaplerotic' originates from Greek, specifically the word 'anaplerōtikos,' where 'ana-' meant 'up, again' and 'plēroun' meant 'to fill.'

'anaplerōtikos' was adopted into Late Latin as 'anapleroticus,' and eventually became the modern English word 'anaplerotic.'

Initially, it meant 'filling up or restoring,' but over time it evolved into its current meaning of 'replenishing intermediates in metabolic pathways.'