'amphiprotic' originates from Greek, specifically the prefix 'amphi-' meaning 'both' and 'protic' from 'proton' meaning 'first' or 'primary particle'.

'amphiprotic' was derived from the Greek word 'amphiprotos' and eventually became the modern English word 'amphiprotic'.

Initially, it meant 'capable of donating or accepting a proton', and this meaning has largely remained the same in modern usage.