'amoebula' originates from the Greek word 'amoibē,' meaning 'change' or 'exchange,' combined with the diminutive suffix '-ula,' indicating a smaller form.

'amoibē' transformed into the Latin word 'amoeba,' and eventually became the modern English word 'amoebula' to denote a smaller form of amoeba.

Initially, it meant 'a small changeable organism,' and this meaning has largely remained the same in modern usage.