'ambisinister' originates from Latin, specifically the word 'ambisinister,' where 'ambi-' meant 'both' and 'sinister' meant 'left-handed or unfavorable.'

'ambisinister' changed from the Latin word 'ambisinister' and has remained largely unchanged in modern English.

Initially, it meant 'unfavorable or clumsy with both hands,' and this meaning has largely remained the same in modern usage.