'agmatine' originates from the German word 'Agmatin', which was derived from 'Agmatin' in reference to its discovery as a decarboxylation product of arginine.

'Agmatin' was first identified in the late 19th century and has since been recognized as a significant compound in biochemical research.

Initially, it was identified as a simple decarboxylation product, but over time it evolved into its current understanding as a neurotransmitter modulator.