'agammaglobulinemic' originates from Greek, specifically the prefix 'a-' meaning 'without', 'gamma' referring to a type of globulin, and 'emic' relating to blood conditions.

'agammaglobulinemic' changed from the Greek word 'agammaglobulinemia' and eventually became the modern English word 'agammaglobulinemic'.

Initially, it meant 'without gamma globulins in the blood', and this meaning has largely remained the same in modern usage.