'U.S.-inspired' originates from English, specifically the abbreviation 'U.S.' (from 'United States') combined with 'inspired', the past participle of 'inspire' (from Latin 'inspirare').

'inspired' derives from Latin 'inspirare' ('in-' + 'spirare' meaning 'to breathe into'), passed into Middle English via Old French forms; 'U.S.' developed as the abbreviation for 'United States' in the late 18th century. The two elements were joined in modern English to form the compound adjective 'U.S.-inspired'.

Originally 'inspire' carried the sense 'to breathe into' or 'to fill with a spirit/feeling'; in modern compounds like 'U.S.-inspired' the sense has shifted to 'influenced by' or 'motivated by' the named source (the United States).