NTPDase
|en-tee-pee-dase|
/ɛnˌtiːpiːˈdeɪs/
enzyme family that hydrolyzes extracellular nucleoside tri-/diphosphates
Etymology
'NTPDase' originates from English, specifically the phrase 'nucleoside triphosphate diphosphohydrolase', where 'nucleoside' referred to a nucleoside, 'triphosphate' meant 'three phosphate groups', 'diphospho' indicated linked phosphate units, and the suffix '-hydrolase' denoted an enzyme catalyzing hydrolysis.
'NTPDase' was formed in modern biochemical nomenclature as an abbreviation (initialism/acronym) of 'nucleoside triphosphate diphosphohydrolase' and later adopted as the standard name for a family of ectoenzymes and their gene/isoenzyme designations (for example, NTPDase1, often also called ENTPD1).
Initially the full phrase described an enzymatic activity (hydrolysis of nucleoside tri- and diphosphates). Over time the abbreviated form 'NTPDase' came to be used as the family/isoenzyme name in biochemical and genetic nomenclature.
Meanings by Part of Speech
Noun 1
abbreviation for nucleoside triphosphate diphosphohydrolase, a family of membrane-associated ectoenzymes that hydrolyze extracellular nucleoside tri- and diphosphates (e.g., ATP, ADP) to monophosphates (e.g., AMP). Used to refer both to the enzymatic activity and to specific isoenzymes (e.g., NTPDase1).
Researchers measured NTPDase activity on the surface of endothelial cells to study extracellular ATP signaling.
Synonyms
Last updated: 2025/12/07 21:50