'GUI-related' originates from English, specifically the abbreviation 'GUI' (short for 'graphical user interface') combined with the adjective 'related'.

'GUI' was coined in the 1970s (notably at Xerox PARC) as an abbreviation of 'graphical user interface'; the adjective 'related' derives from Old French 'relater' and Latin 'relatus' (past participle of 'referre'). These elements were combined in modern English to form 'GUI-related'.

Initially, 'GUI' referred specifically to the then-new graphical user interfaces; 'GUI-related' has consistently meant 'pertaining to graphical user interfaces' and has retained that specialized computing sense as the term became widespread.