'Anglophobe' originates from a combination of elements: the prefix 'Anglo-' (from Latin 'Anglia', referring to England) and the Greek-derived suffix '-phobe' (from Greek 'phobos', meaning 'fear').

'Anglophobe' was formed in modern European languages (19th century onward) under influence from words like French 'anglophobe' and the abstract noun 'Anglophobia', and it entered English as the noun 'Anglophobe' (singular), with the plural 'Anglophobes'.

Initially formed to denote hostility or opposition toward England or English influence, it has come to mean more broadly 'a person who fears or dislikes England, English people, or English culture' in contemporary usage.