'Anastasio' originates from Greek, specifically the word 'Anastasios', where 'anastasis' meant 'resurrection' (from the verb 'anistēmi' meaning 'to raise up').

'Anastasio' changed from Greek 'Anastasios' into Latin 'Anastasius', passed through Medieval Latin and Romance-language forms, and eventually became the modern Spanish/Italian given name 'Anastasio'.

Initially it meant 'of the resurrection' or 'one who is resurrected' in a religious/textual sense; over time it became used primarily as a personal name.