'AChE' originates from the abbreviation of 'acetylcholinesterase', where 'acetyl' refers to the acetyl group, 'choline' is a neurotransmitter, and 'esterase' is an enzyme that breaks down esters.

The term 'acetylcholinesterase' was coined in the early 20th century as the understanding of neurotransmitters and enzymes developed.

Initially, it was identified as an enzyme involved in neurotransmission, and this meaning has remained consistent.